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I got this same code on my 03 RSX Type s. I replaced the evap canister and the purge valve. I think it may be that the actual wires in the connector become damaged. Talking about the orange plug/connector that plugs into the evap canister. Will see what I can find.
I am getting the same P0453 code on my 2007 RDX along with P2422, Replaced the FTP Sensor (yellow Circle), Purge valve is open (red Arrow), can plow air thru canister. I Haven't replaced the Fuel cap yet.