Hello,

My door lock squeaks only when unlocking. Generally happens more often when the weather is cold versus warm outside. Here's a video:
How can I fix that?

 

You replace the actuator. But it's not needed as long as the door locks and unlocks.

 

Pretty much all of our Hondas/Acuras have had door lock actuators that "complain" or as OP mentions - squeaked at one point or another. We did have one completely fail which was replaced under warranty, but never replaced one that was making noise.