My question for anyone running this combo is if you've noticed any negative impacts or lean conditions? If you have flashpro then you'll obviously notice that theres only the reflashed calibration available for our years as opposed to the 6 or 7 calibrations available for 07-09. I want to purchase the CP-e but want to avoid any situation where I have to do any additional tuning. Thanks in advanced.

 

Here is a good reference for you surrounding hondata's testing with the CP-E intake.
Reflash - Acura RDX

If that is the only part you are going to add, just do the reflash.
If you are worried about running to lean, i'd do the flashpro along with a custom tune from E-tunez.
ECU Tuning for Hondata, K-tuner, Cobb and more... | E-Tunez