my 05 tl 6sp is making a clicking noise coming from the driver side whenever i accelerate also when the clutch engages during driving. I dont know whats causing the problem. Could it be my axel?

 

check your CV joints. Jack car up and look at axles. typically the boots tear on the outer joints.

 

x2

also is it just one click when you take off?

if so check the torque spec on the axle nut. Some honda/acuras have a tsb for low torque spec of the axle nut.

Pretty much loosen, apply grease, re torque to a little over 200lbs/ft